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國家衛(wèi)健委功能性腦疾病診治重點實驗室

研究員

科副主任

職務(wù):科副主任

基本情況

重慶醫(yī)科大學(xué)附屬第一醫(yī)院,神經(jīng)內(nèi)科副主任。副主任醫(yī)師,研究員,博士研究生導(dǎo)師。教育部長江學(xué)者青年學(xué)者,重慶市杰出青年基金獲得者,重慶市十佳科技青年,重慶市學(xué)術(shù)技術(shù)帶頭人后備人選,重慶市青年專家工作室首席專家。現(xiàn)任重慶市醫(yī)學(xué)會神經(jīng)內(nèi)科學(xué)分會副主任委員、中華醫(yī)學(xué)會神經(jīng)病學(xué)分會青年學(xué)組委員、中華醫(yī)學(xué)會神經(jīng)病學(xué)分會神經(jīng)調(diào)控協(xié)作組委員。任SCI期刊Translational Psychiatry編委。

2014年獲重慶市科委青年拔尖人才稱號,2016年獲中國科協(xié)“青年人才托舉工程”、重慶醫(yī)科大學(xué)附屬第一醫(yī)院優(yōu)秀共產(chǎn)黨員,2017年獲重慶市市委組織部高層次人才、重慶市教委優(yōu)秀教師,2018年獲首屆生理協(xié)會腦科學(xué)青年科學(xué)家獎、中國醫(yī)師協(xié)會神經(jīng)內(nèi)科分會“十大杰出青年醫(yī)師”及重慶市教委十大杰出成果。

以第一作者/通訊(含共同)在Advanced Sciences、Molecular Psychiatry (3篇), Science Advances等發(fā)表18篇SCI論文,被Cell、Nature等他引1000余次,1篇高被引(top 1%),1篇熱點論文(top 0.1%)。相關(guān)成果獲重慶市科技進步一等獎1項(排3)、中華醫(yī)學(xué)科技進步一等獎1項(排11)各1項。獲國家重點研發(fā)計劃1項(課題組長),國家自然科學(xué)基金4項,獲國家發(fā)明專利1項(排2)。

研究方向(含承擔(dān)課題)

近10 年來以發(fā)現(xiàn)的抑郁癥伴有顯著的微生物源代謝紊亂這一重要臨床新線索為起點,鎖定腸道微生物組這一內(nèi)外環(huán)境的鏈接點,拓展出抑郁癥的“微生物-腸-腦”軸這一新研究領(lǐng)域,聚焦于抑郁癥腸-腦機制及臨床轉(zhuǎn)化研究,利用大量臨床數(shù)據(jù)及高通量測序技術(shù),取得了成體系、有特色、具有一定國際影響力的原創(chuàng)成果:1. 率先挖掘出抑郁癥伴腸道微生物紊亂的臨床證據(jù),闡明了腸道微生物組紊亂是抑郁癥發(fā)病的潛在原因,并揭示其導(dǎo)致抑郁的 “腸-腦”代謝機制;2. 構(gòu)建首個抑郁猴及抑郁癥患者腸道宏基因數(shù)據(jù)集,明確擬桿菌科富集是抑郁癥的特征性改變;創(chuàng)新開展“三步篩菌法”,鑒定出9種致抑郁擬桿菌菌種。

著作論文

1. Huang Y, Wu J, Zhang H, Li Y, Wen L, Tan X, Cheng K, Liu Y, Pu J, Liu L, Wang H, Li W, Perry SW, Wong ML, Licinio J, Zheng P*, Xie P*. The gut microbiome modulates the transformation of microglial subtypes. Mol Psychiatry. (2023)

2. Zheng P#., Wu J#., Zhang H., Perry S. W., Yin B., Tan X., Chai T., Liang W., Huang Y., Li Y., Duan J., Wong M. L., Licinio J., Xie P*. The gut microbiome modulates gut-brain axis glycerophospholipid metabolism in a region-specific manner in a nonhuman primate model of depression. Mol Psychiatry (2021) 26(6):2380-2392

3. Yang J#, Zheng P#, Li Y, Wu J, Tan X, Zhou J, Sun Z, Chen X, Zhang G, Zhang H, Huang Y, Chai T, Duan J, Liang W, Yin B, Lai J, Huang T, Du Y, Zhang P, Jiang J, Xi C, Wu L, Lu J, Mou T, Xu Y, Perry SW, Wong ML, Licinio J, Hu S*, Wang G*, Xie P*. Landscapes of bacterial and metabolic signatures and their interaction in major depressive disorders.Science advances(2020) 2;6(49): eaba8555.

4. Zheng P#., Yang J#., Li Y., Wu J., Liang W., Yin B., Tan X., Huang Y., Chai T., Zhang H., Duan J., Zhou J., Sun Z., Chen X., Marwari S., Lai J., Huang T., Du Y., Zhang P., Perry S. W., Wong M. L., Licinio J., Hu S*., Xie P*., Wang G*. Gut Microbial Signatures Can Discriminate Unipolar from Bipolar Depression[J]. Adv Sci (Weinh)(2020) 7(7): 1902862

5. Wang X, Liu H, Li Y, Huang S, Zhang L, Cao C, Baker PN, Tong C, Zheng P*, Qi H*. Altered gut bacterial and metabolic signatures and their interaction in gestational diabetes mellitus. Gut Microbes. (2020) 9;12(1):1-13

6. Zheng P#, Li Y#, Wu J, Zhang H, Huang Y, Tan X, Pan J, Duan J, Liang W, Yin B, Deng F, Perry SW, Wong ML, Licinio J, Wei H*, Yu G*, Xie P*. Perturbed microbial ecology in myasthenia gravis: evidence from the gut microbiome and fecal metabolome. Advanced Science. (2019) 31;6(18):1901441.

7. Zheng P#, Zeng B#, Liu M#, Chen J#, Pan J, Han Y, Liu Y, Cheng K, Zhou C, Wang H, Zhou X, Gui S, Perry SW, Wong ML, Licinio J, Wei H*, Xie P*. The gut microbiome from patients with schizophrenia modulates the glutamate-glutamine-GABA cycle and schizophrenia-relevant behaviors in mice.Sci Adv. (2019) 6;5(2): eaau8317

8. Pan JX#, Xia JJ#, Deng FL, Liang WW, Wu J, Yin BM, Dong MX, Chen JJ, Ye F, Wang HY, Zheng P*, Xie P*. Diagnosis of major depressive disorder based on changes in multiple plasma neurotransmitters: a targeted metabolomics studyTransl Psychiatry. (2018) 10;8(1):130

9. Zheng P#, Cheng K#, Zeng L#, Zhou CJ#, Xie P*. A new pathway for the gut microbiota to modulate the brain: activation of pattern-recognition receptors by microbial products. Molecular Psychiatry(2017) 22(2):162-163

10. Zheng P#, Zeng B#, Zhou C#, Liu M#, Fang Z, Xu X, Zeng L, Chen J, Fan S, Du X, Zhang X, Yang D, Yang Y, Meng H, Li W, Melgiri ND, Licinio J*, Wei H*, Xie P*. Gut microbiome remodeling induces depressive-like behaviors through a pathway mediated by the host’s metabolism. Molecular Psychiatry (2016) 21(6):786-96

11. Zheng P#, Chen JJ#, Zhou CJ, Zeng L, Li KW, Sun L, Liu M-L, Zhu D, Liang ZH, and Xie P*. Identification of sex-specific urinary biomarkers for major depressive disorder by combined application of NMR- and GC–MS-based metabonomics. Transl Psychiatry (2016) 15;6(11):e955

12. Zheng P#,F(xiàn)ang Z#,Xu XJ,Liu ML,Du X,Zhang X,Wang H,Zhou J,Xie P*. Metabolite signature for diagnosing major depressive disorder in peripheral blood mononuclear cells. Journal of affective disorders (2016) 195, 75-81

13. Liu X#, Zheng P#, Zhao X, Zhang Y, Hu C, Li J, Zhao J, Zhou J, Xie P*, Xu G*. Discovery and validation of plasma biomarkers for major depressive disorder classification based on liquid chromatography-mass spectrometry.J Proteome Res(2015) 5(1 4):2322-2330

14. Xu XJ#, Zheng P#, Ren GP, Liu ML, Mu J, Guo J, Cao D, Liu Z, Meng HQ*, Xie P*. 2, 4-Dihydroxypyrimidine is a potential urinary metabolite biomarker for diagnosing bipolar disorder. Molecular BioSystems (2014),10:813-819

15. Liu ML#, Zheng P#, Liu Z, Xu Y, Mu J, Guo J, Huang T, Meng HQ*, Xie Peng*. GC-MS based metabolomics identification of possible novel biomarkers for schizophrenia in peripheral blood mononuclear cells. Molecular BioSystems (2014) 10(9): 2398-406

16. Zheng P#, Gao HC#, Qi ZG, Jia JM, Li FF, Chen JJ, Wang Y, Guo J, Melgiri ND, Xie P*. Peripheral metabolic abnormalities of lipids and amino acids implicated in increased risk of suicidal behavior in major depressive disorder. Metabolomics. (2013) 9 (3), 688-696

17. Zheng P#, Chen JJ#, Huang T, Wang MJ, Wang Y, Dong MX, Huang YJ, Zhou LK & Xie P*. A Novel Urinary Metabolite Signature for Diagnosing Major Depressive Disorder.J. Proteome Res (2013) 12 (12), 5904–5911

18. Zheng P#, Wei YD#, Yao GE, Ren GP, Guo J, Zhou CJ, Zhong JJ, Cao D, Zhou LK, Xie P*. Novel urinary biomarkers for diagnosing bipolar disorder. Metabolomics (2013) 9 (4), 800-808

19. Zheng P#, Wang Y#, Chen L, Yang D, Meng H, Zhou D, Zhong J, Lei Y, Melgiri ND, Xie P*. Identification and validation of urinary metabolite biomarkers for major depressive disorder.  Molecular & Cellular Proteomics (2013),12(1):207-14

20. Zheng P#, Gao HC#, Li Q, Shao WH, Zhang ML, Cheng K, Yang de Y, Fan SH, Chen L, Fang L, Xie P*. Plasma metabonomics as a novel diagnostic approach for major depressive dorder. J Proteome Res(2012) 11 (3):1741-1748

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