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導(dǎo)航菜單
重慶醫(yī)科大學(xué)附屬第一醫(yī)院,神經(jīng)內(nèi)科副主任。副主任醫(yī)師,研究員,博士研究生導(dǎo)師。教育部長(zhǎng)江學(xué)者青年學(xué)者,重慶市杰出青年基金獲得者,重慶市十佳科技青年,重慶市學(xué)術(shù)技術(shù)帶頭人后備人選,重慶市青年專家工作室首席專家。現(xiàn)任重慶市醫(yī)學(xué)會(huì)神經(jīng)內(nèi)科學(xué)分會(huì)副主任委員、中華醫(yī)學(xué)會(huì)神經(jīng)病學(xué)分會(huì)青年學(xué)組委員、中華醫(yī)學(xué)會(huì)神經(jīng)病學(xué)分會(huì)神經(jīng)調(diào)控協(xié)作組委員。任SCI期刊Translational Psychiatry編委。
2014年獲重慶市科委青年拔尖人才稱號(hào),2016年獲中國(guó)科協(xié)“青年人才托舉工程”、重慶醫(yī)科大學(xué)附屬第一醫(yī)院優(yōu)秀共產(chǎn)黨員,2017年獲重慶市市委組織部高層次人才、重慶市教委優(yōu)秀教師,2018年獲首屆生理協(xié)會(huì)腦科學(xué)青年科學(xué)家獎(jiǎng)、中國(guó)醫(yī)師協(xié)會(huì)神經(jīng)內(nèi)科分會(huì)“十大杰出青年醫(yī)師”及重慶市教委十大杰出成果。
以第一作者/通訊(含共同)在Advanced Sciences、Molecular Psychiatry (3篇), Science Advances等發(fā)表18篇SCI論文,被Cell、Nature等他引1000余次,1篇高被引(top 1%),1篇熱點(diǎn)論文(top 0.1%)。相關(guān)成果獲重慶市科技進(jìn)步一等獎(jiǎng)1項(xiàng)(排3)、中華醫(yī)學(xué)科技進(jìn)步一等獎(jiǎng)1項(xiàng)(排11)各1項(xiàng)。獲國(guó)家重點(diǎn)研發(fā)計(jì)劃1項(xiàng)(課題組長(zhǎng)),國(guó)家自然科學(xué)基金4項(xiàng),獲國(guó)家發(fā)明專利1項(xiàng)(排2)。
1. Huang Y, Wu J, Zhang H, Li Y, Wen L, Tan X, Cheng K, Liu Y, Pu J, Liu L, Wang H, Li W, Perry SW, Wong ML, Licinio J, Zheng P*, Xie P*. The gut microbiome modulates the transformation of microglial subtypes. Mol Psychiatry. (2023)
2. Zheng P#., Wu J#., Zhang H., Perry S. W., Yin B., Tan X., Chai T., Liang W., Huang Y., Li Y., Duan J., Wong M. L., Licinio J., Xie P*. The gut microbiome modulates gut-brain axis glycerophospholipid metabolism in a region-specific manner in a nonhuman primate model of depression. Mol Psychiatry (2021) 26(6):2380-2392
3. Yang J#, Zheng P#, Li Y, Wu J, Tan X, Zhou J, Sun Z, Chen X, Zhang G, Zhang H, Huang Y, Chai T, Duan J, Liang W, Yin B, Lai J, Huang T, Du Y, Zhang P, Jiang J, Xi C, Wu L, Lu J, Mou T, Xu Y, Perry SW, Wong ML, Licinio J, Hu S*, Wang G*, Xie P*. Landscapes of bacterial and metabolic signatures and their interaction in major depressive disorders.Science advances(2020) 2;6(49): eaba8555.
4. Zheng P#., Yang J#., Li Y., Wu J., Liang W., Yin B., Tan X., Huang Y., Chai T., Zhang H., Duan J., Zhou J., Sun Z., Chen X., Marwari S., Lai J., Huang T., Du Y., Zhang P., Perry S. W., Wong M. L., Licinio J., Hu S*., Xie P*., Wang G*. Gut Microbial Signatures Can Discriminate Unipolar from Bipolar Depression[J]. Adv Sci (Weinh)(2020) 7(7): 1902862
5. Wang X, Liu H, Li Y, Huang S, Zhang L, Cao C, Baker PN, Tong C, Zheng P*, Qi H*. Altered gut bacterial and metabolic signatures and their interaction in gestational diabetes mellitus. Gut Microbes. (2020) 9;12(1):1-13
6. Zheng P#, Li Y#, Wu J, Zhang H, Huang Y, Tan X, Pan J, Duan J, Liang W, Yin B, Deng F, Perry SW, Wong ML, Licinio J, Wei H*, Yu G*, Xie P*. Perturbed microbial ecology in myasthenia gravis: evidence from the gut microbiome and fecal metabolome. Advanced Science. (2019) 31;6(18):1901441.
7. Zheng P#, Zeng B#, Liu M#, Chen J#, Pan J, Han Y, Liu Y, Cheng K, Zhou C, Wang H, Zhou X, Gui S, Perry SW, Wong ML, Licinio J, Wei H*, Xie P*. The gut microbiome from patients with schizophrenia modulates the glutamate-glutamine-GABA cycle and schizophrenia-relevant behaviors in mice.Sci Adv. (2019) 6;5(2): eaau8317
8. Pan JX#, Xia JJ#, Deng FL, Liang WW, Wu J, Yin BM, Dong MX, Chen JJ, Ye F, Wang HY, Zheng P*, Xie P*. Diagnosis of major depressive disorder based on changes in multiple plasma neurotransmitters: a targeted metabolomics study. Transl Psychiatry. (2018) 10;8(1):130
9. Zheng P#, Cheng K#, Zeng L#, Zhou CJ#, Xie P*. A new pathway for the gut microbiota to modulate the brain: activation of pattern-recognition receptors by microbial products. Molecular Psychiatry(2017) 22(2):162-163
10. Zheng P#, Zeng B#, Zhou C#, Liu M#, Fang Z, Xu X, Zeng L, Chen J, Fan S, Du X, Zhang X, Yang D, Yang Y, Meng H, Li W, Melgiri ND, Licinio J*, Wei H*, Xie P*. Gut microbiome remodeling induces depressive-like behaviors through a pathway mediated by the host’s metabolism. Molecular Psychiatry (2016) 21(6):786-96
11. Zheng P#, Chen JJ#, Zhou CJ, Zeng L, Li KW, Sun L, Liu M-L, Zhu D, Liang ZH, and Xie P*. Identification of sex-specific urinary biomarkers for major depressive disorder by combined application of NMR- and GC–MS-based metabonomics. Transl Psychiatry (2016) 15;6(11):e955
12. Zheng P#,F(xiàn)ang Z#,Xu XJ,Liu ML,Du X,Zhang X,Wang H,Zhou J,Xie P*. Metabolite signature for diagnosing major depressive disorder in peripheral blood mononuclear cells. Journal of affective disorders (2016) 195, 75-81
13. Liu X#, Zheng P#, Zhao X, Zhang Y, Hu C, Li J, Zhao J, Zhou J, Xie P*, Xu G*. Discovery and validation of plasma biomarkers for major depressive disorder classification based on liquid chromatography-mass spectrometry.J Proteome Res(2015) 5(1 4):2322-2330
14. Xu XJ#, Zheng P#, Ren GP, Liu ML, Mu J, Guo J, Cao D, Liu Z, Meng HQ*, Xie P*. 2, 4-Dihydroxypyrimidine is a potential urinary metabolite biomarker for diagnosing bipolar disorder. Molecular BioSystems (2014),10:813-819
15. Liu ML#, Zheng P#, Liu Z, Xu Y, Mu J, Guo J, Huang T, Meng HQ*, Xie Peng*. GC-MS based metabolomics identification of possible novel biomarkers for schizophrenia in peripheral blood mononuclear cells. Molecular BioSystems (2014) 10(9): 2398-406
16. Zheng P#, Gao HC#, Qi ZG, Jia JM, Li FF, Chen JJ, Wang Y, Guo J, Melgiri ND, Xie P*. Peripheral metabolic abnormalities of lipids and amino acids implicated in increased risk of suicidal behavior in major depressive disorder. Metabolomics. (2013) 9 (3), 688-696
17. Zheng P#, Chen JJ#, Huang T, Wang MJ, Wang Y, Dong MX, Huang YJ, Zhou LK & Xie P*. A Novel Urinary Metabolite Signature for Diagnosing Major Depressive Disorder.J. Proteome Res (2013) 12 (12), 5904–5911
18. Zheng P#, Wei YD#, Yao GE, Ren GP, Guo J, Zhou CJ, Zhong JJ, Cao D, Zhou LK, Xie P*. Novel urinary biomarkers for diagnosing bipolar disorder. Metabolomics (2013) 9 (4), 800-808
19. Zheng P#, Wang Y#, Chen L, Yang D, Meng H, Zhou D, Zhong J, Lei Y, Melgiri ND, Xie P*. Identification and validation of urinary metabolite biomarkers for major depressive disorder. Molecular & Cellular Proteomics (2013),12(1):207-14
20. Zheng P#, Gao HC#, Li Q, Shao WH, Zhang ML, Cheng K, Yang de Y, Fan SH, Chen L, Fang L, Xie P*. Plasma metabonomics as a novel diagnostic approach for major depressive dorder. J Proteome Res(2012) 11 (3):1741-1748
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