1）研究方向：抑郁癥的分子機(jī)制研究。

2) 擅長(zhǎng)技術(shù)：熟練掌握常規(guī)分子生物學(xué)（WB, PCR，ELISA，IF，RNAscope等），293細(xì)胞系和海馬原代神經(jīng)元培養(yǎng)。熟練操作腦片全細(xì)胞膜片鉗記錄和海馬場(chǎng)電位記錄和抑郁模型建模/轉(zhuǎn)基因小鼠抑郁模型及抑郁焦慮相關(guān)行為學(xué)評(píng)估。大/小鼠腦立體定位注射和埋管手術(shù)。人腦腦片多通道膜片鉗記錄和掃描電鏡等技術(shù)。

1. Ke Cheng^#, et al, Hua-tai Xu, Peng Xie. The deficit of hippocampal carbonic anhydrase 1 causes depression-like behaviors. Acta Neuropathologica Communications 2023 Apr 3;11(1):59. (IF:7.5)

2. Wang Y, Chen X, Chen Z, Yu H, Tian Y, He Y, Cheng K, Xie P. Disturbances of phosphatidylcholines metabolism in major depressive disorder CNS Spectr. 2023 Jan 17:1-9.

3. Cheng, K^#., Li, J., Yang, D., Yang, Y., Rao, C., Zhang, S., Wang, W., Guo, H., Fang, L., Zhu, D., et al. (2016). 2D-gel based proteomics unravels neurogenesis and energetic metabolism dysfunction of the olfactory bulb in CUMS rat model. Behavioural brain research 313, 302-309.

4. Mengge Bai , et., al, Ke Cheng*, Peng Xie. (2022) Pigment epithelium-derived factor may induce antidepressant phenotypes in mice by the prefrontal cortex. Neuroscience Letter. DOI: 10.1016/j.neulet.2021.136423

5. Jie Liu, et., al, Ke Cheng*, Peng Xie.(2020) Changed PGA and POSTN levels in choroid plexus are associated with depressive-like behaviors in mice. Biochemical and Biophysical Research Communications. DOI: 10.1016/j.bbrc.2020.01.076.

6. Yan Li, et., al, Ke Cheng*, Peng Xie. (2022), The Neurotransmitter and Related Metabolite of GABAergic, Serotonergic and Catecholaminergic Pathway Changed in the Nucleus Accumbens of CUMS Rats. Frontiers in Behavioral Neuroscience.

7.Chenmeng Li,  Ke Cheng., Activation of ERK/CREB/BDNF pathway involved in abnormal behavior of neonatally Borna virus-infected rats. Neuropsychiatr Dis Treat. 2018 Nov 15;14:3121-3132. doi: 10.2147/NDT.S176399. eCollection 2018.

8. Yong He, et., al, Ke Cheng*, Peng Xie.(2019) The 25(OH)D/VDR signaling may play a role in major depression. Biochemical and Biophysical Research Communications. DOI: 10.1016/j.bbrc.2019.12.071.

9. Yue Wang, et., al, Ke Cheng*, Peng Xie. (2021) Ferritin disorder in plasma and hippocampus associated with major depressive disorder. Biochemical and Biophysical Research Communications. DOI:10.1016/j.bbrc.2021.03.059

10. Yong He, et al, Ke Cheng*, Peng Xie*. (2020) Major depression accompanied with inflammation and multiple cytokines alterations: Evidences from clinical patients to macaca fascicularis and LPS-induced depressive mice model. Journal of Affective Disorders.doi.org/10.1016/j.jad.2020.03.131.