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國家衛(wèi)健委功能性腦疾病診治重點實驗室
導航菜單
基本情況
2017年畢業(yè)于重慶醫(yī)科大學神經病學博士，2019年重慶醫(yī)科大學基礎醫(yī)學院病理生理博士后,臨港國家實驗室助理研究員，重慶醫(yī)科大學附屬永川醫(yī)院神內科，腦血管病研究重慶市重點實驗室PI。“Elife”雜志簽約editor。
研究方向(含承擔課題)
1）研究方向：抑郁癥的分子機制研究。
2) 擅長技術：熟練掌握常規(guī)分子生物學（WB, PCR，ELISA，IF，RNAscope等），293細胞系和海馬原代神經元培養(yǎng)。熟練操作腦片全細胞膜片鉗記錄和海馬場電位記錄和抑郁模型建模/轉基因小鼠抑郁模型及抑郁焦慮相關行為學評估。大/小鼠腦立體定位注射和埋管手術。人腦腦片多通道膜片鉗記錄和掃描電鏡等技術。
著作論文
1. Ke Cheng#, et al, Hua-tai Xu, Peng Xie. The deficit of hippocampal carbonic anhydrase 1 causes depression-like behaviors. Acta Neuropathologica Communications 2023 Apr 3;11(1):59. (IF:7.5)
2. Wang Y, Chen X, Chen Z, Yu H, Tian Y, He Y, Cheng K, Xie P. Disturbances of phosphatidylcholines metabolism in major depressive disorder CNS Spectr. 2023 Jan 17:1-9.
3. Cheng, K#., Li, J., Yang, D., Yang, Y., Rao, C., Zhang, S., Wang, W., Guo, H., Fang, L., Zhu, D., et al. (2016). 2D-gel based proteomics unravels neurogenesis and energetic metabolism dysfunction of the olfactory bulb in CUMS rat model. Behavioural brain research 313, 302-309.
4. Mengge Bai , et., al, Ke Cheng*, Peng Xie. (2022) Pigment epithelium-derived factor may induce antidepressant phenotypes in mice by the prefrontal cortex. Neuroscience Letter. DOI: 10.1016/j.neulet.2021.136423
5. Jie Liu, et., al, Ke Cheng*, Peng Xie.(2020) Changed PGA and POSTN levels in choroid plexus are associated with depressive-like behaviors in mice. Biochemical and Biophysical Research Communications. DOI: 10.1016/j.bbrc.2020.01.076.
6. Yan Li, et., al, Ke Cheng*, Peng Xie. (2022), The Neurotransmitter and Related Metabolite of GABAergic, Serotonergic and Catecholaminergic Pathway Changed in the Nucleus Accumbens of CUMS Rats. Frontiers in Behavioral Neuroscience.
7.Chenmeng Li, Ke Cheng., Activation of ERK/CREB/BDNF pathway involved in abnormal behavior of neonatally Borna virus-infected rats. Neuropsychiatr Dis Treat. 2018 Nov 15;14:3121-3132. doi: 10.2147/NDT.S176399. eCollection 2018.
8. Yong He, et., al, Ke Cheng*, Peng Xie.(2019) The 25(OH)D/VDR signaling may play a role in major depression. Biochemical and Biophysical Research Communications. DOI: 10.1016/j.bbrc.2019.12.071.
9. Yue Wang, et., al, Ke Cheng*, Peng Xie. (2021) Ferritin disorder in plasma and hippocampus associated with major depressive disorder. Biochemical and Biophysical Research Communications. DOI:10.1016/j.bbrc.2021.03.059
10. Yong He, et al, Ke Cheng*, Peng Xie*. (2020) Major depression accompanied with inflammation and multiple cytokines alterations: Evidences from clinical patients to macaca fascicularis and LPS-induced depressive mice model. Journal of Affective Disorders.doi.org/10.1016/j.jad.2020.03.131.
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