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國(guó)家衛(wèi)健委功能性腦疾病診治重點(diǎn)實(shí)驗(yàn)室

研究方向(含承擔(dān)課題)

借助系統(tǒng)行為學(xué),光纖記錄,光遺傳和化學(xué)遺傳,離體和在體電生理,分子生化等技術(shù)手段研究慢性應(yīng)激導(dǎo)致抑郁的分子,細(xì)胞和神經(jīng)環(huán)路機(jī)制。

著作論文

1. Yong He#, Yue Wang#, Heming Yu, Yu Tian, Xiangyu Chen, Chong Chen, Yikun Ren, Zhi Chen, Yi Ren, Xue Gong, Ke Cheng, Xiaolei Liu, Lianmei Zhong*, Yi Guo*,Peng Xie*Protective effect of Nr4a2 (Nurr1) against LPS-induced depressive-like behaviors via regulating activity of microglia and CamkII neurons in anterior cingulate cortex. Pharmacological research, 2023 Mar 21;191:106717,doi: 10.1016/j.phrs.2023.106717.

2. Yong He, Wei Li, Yue Wang, Yu Tian, Xi Chen, Zhonghao Wu, Tianlan Lan, Yan Li, Mengge Bai, Jie Liu, Ke Chen*, Peng Xie*Journal of Affective disorders, Volume 271,15 June 2020, Pages 262-271,doi:10.1016/j.jad.2020.03.131.

3. Yong He, Yue Wang, Zhonghao Wu, Tianlan Lan, Yu Tian, Xi Chen, Yan Li, Ruozhi Dang, Mengge Bai, Ke Cheng*, Peng Xie*. Metabolomic abnormalities of purine and lipids implicated olfactory bulb dysfunction of CUMS depressive ratsMetabolic Brain Disease, 2020 Apr; 35(4);649-659;doi:10.1007/s11011-020-00557-8.

4. Yong He#,, Zhonghao Wu#,, Tianlan Lan, Yue Wang, Yu Tian, Xi Chen, Yan Li, Mengge Bai, Jie Liu, Xue Gong, Ke Cheng*, Peng Xie*.The 25(OH)D/VDR signaling may play a role in major depression (Biochemical and Biophysical Research Communication, 2020 Mar 5;523(2):405-410. doi: 10.1016/j.bbrc.2019.12.071.

5. Yong He#, Wei Li#,, Yu Tian#,, Xi Chen#,, Ke Cheng#,, Ke Xu, Chenmeng Li, Haiyang Wang, Chaohua Qu, Chunlian Wang, Pengfei Li, Huanxin Chen*, Peng Xie*iTRAQ-based proteomics suggests LRP6, NPY and NPY2R perturbation in the hippocampus involved in CSDS may induce resilience and susceptibility. Life Sciences, 2018 Oct 15;211:102-117. doi: 10.1016/j.lfs.2018.09.016.

6. Xi Chena#, Yong He#, Yu Tianb#, Yue Wang# , Zhonghao Wu, Tianlan Lan, Haiyang Wang, Ke Cheng*, Peng Xie*Different serotypes of AAV vectors and lentivirus meditated tropism in choroid plexus by intracerebroventricular delivery

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